Architectural design processes and workflows are traditionally driven by functional requirements and structural hierarchy of materials. Nature on the other hand, is impartial to the complex sequences of the synthesis of materials that integrate in a coherent process of morphogenesis. Despite the revolution in computation aided design and interdisciplinary upgradations in the digital fabrication technologies, architectural design processes fail to acknowledge the machines, tools and processes used for fabrication. The realization of specific fabrication processes and their individual constraints often lead to amendments to an already established workflow by making desperate adjustments to rationalize the design. Our goal is to introduce design processes which are based on the knowledge of the fabrication tools and which incorporate material properties, constraints, tolerances, machine limitations and interactivity inside it. Those intentions and strategies are embedded inside the design workflow through a series of algorithmic strategies for interactive simulation, optimization and digital fabrication of architectural projects in 1:1 scale. Advanced computational tools open new possibilities and demonstrate a precise construction logic from early design stages, having control of cost. Based on the concept of in-vivo, in-silico, in-vitro architecture, the use of insilico tools challenge the philosophical concept of “HomoFaber” which refers to humans controlling the environment with tools. Architects with no space, with no location fixed, nor country, but with an extreme wish of cultivation of artificial environments for people that had emerged from open platform studies, cloud storage, open source software and compromised on local materialities and therefore on the tectonics.