The Center of Plant Systems Biology and Biotechnology (CPSBB) was established as an autonomous legal research entity in Plovdiv, Bulgaria, in 2015 with the help of the H2020 Teaming project PlantaSYST. The CPSBB has the support of five major partner organizations, as well as the support of the Bulgarian Government, Plovdiv Municipality, and several universities, research institutes, and companies across the world.