The Institute of Informatics & Telecommunications (IIT) is characterised by its focus on Intelligent Computing and Networking, ranging from network equipment and communication protocols, to multimodal content analysis with Artificial Intelligence techniques, and, finally, the application of integrated solutions in multiple applications fields. IIT heavily invests on research around Artificial Intelligence, Augmented and Virtual Reality, 5G networks, with significant results on each field. Its close ties with industrial stakeholders and particularly innovative start-ups and spinoffs of Lefkippos Technology Park further facilitate the rapid incorporation of research results in products and services with huge financial and social impact. However, an even more important aspect of IIT’s evolution is its major strategic decision to act as the epicenter of Demokritos’ plan for fully embracing AI and data-driven science for its scientific activities. IIT has already established synergies with other Demokritos institutes, where ICT technologies have been exploited in different domains (energy, environment, security, etc.) through various research projects, especially during 2018.