The European Association of Systems Medicine e.V. (EASyM) is a charitable association open to everyone with an interest in personalised medicine and systems medicine. The concept of personalised medicine, or rather P4 medicine (predictive, personalised, preventive, participatory medicine), requires not just the acquisition but also the processing of large amounts of personal data. There are too many factors and interactions playing a role in the progression of complex diseases such as cancer, cardiovascular, inflammatory or metabolic diseases to get any meaningful results out of the raw data. Systems Medicine builds on the integration and analysis of complex data sets through mathematical algorithm and computational modelling. The aim of EASyM is to foster Systems Medicine approaches in experimental medicine and clinical research. EASyM strives to integrate all relevant stakeholders, including clinicians, researchers, medical and patient organisations, industry, funders & policy makers. In particular, EASyM aims to Organise annual conferences Offer Systems Medicine training courses and provide educational material Promote Systems Medicine publications, either through special issues in established journals or establishing a Systems Medicine-dedicated journal Provide comprehensive information and databases about Systems Medicine to the public and to all relevant communities & disciplines Offer intersectoral and interdisciplinary partnering events Organise seminars to discuss interdisciplinary, ethical, societal and economic issues of the implementation of Systems Medicine and the acquisition of personal medical data Offer of contacts, advice and infrastructure for the planning, application and implementation of research and educational programs Become the voice of Systems Medicine in Europe and for the European Commission