Mission Statement: To create an indigenously developed, open-source, comprehensive database of molecular profiles of all cancers prevalent in Indian populations. Specifically, the goal is to characterize the genomic, transcriptomic, epigenetic, and proteomic features of Indian cancers using advanced, next-generation multi-omics technologies. In this public health effort, high-quality meta-data of cancer patients and biospecimens (blood, cancer tissues) representing various clinical scenarios are being ethically collected from various geographical regions of India. Big data generated after multi-omics profiling will be curated and analyzed for correlation with clinicopathological profiles. Such curated databases will be then open-sourced to the Indian and global cancer research communities. Strategy The successful creation and quality of the proposed open-source multi-omics database of Indian cancers will be entirely dependent on the uniformity, sanctity, and integrity of the meta-data and biospecimens collected from various geographical locations. Hence, a pan-India consortium of partners is being established, which will operate as a ‘hub-and-spoke’ model.