PersonalGenomes.org is a 501(c)(3) nonprofit working to generate, aggregate and interpret human biological and trait data on an unprecedented scale. Our mission is to make a wide spectrum of data about humans accessible to increase biological literacy and improve human health. Our efforts are informed by values encouraging greater transparency and collaboration between researchers and participants. The organization supports three major programs and initiatives: Open Humans, Global Network of Personal Genome Projects, and the Genomes, Environments and Traits (GET) Conference. The Global Network of Personal Genome Projects (PGP) is a groundbreaking research initiative founded in 2005 by Harvard Medical School professor George Church as the first “open source” public health project. A primary goal of the PGP is to assemble the world’s richest public data resource composed of human genetic, environmental and trait data donated and curated by volunteers from all over the world. We organize an annual event called the Genomes, Environments, and Traits (GET) Conference where we invite leading thinkers to discuss the important ways in which new genomic technologies will affect all of our lives in the coming years and to debate their technical, commercial, and societal impacts. The GET Conference is a forum that brings together research communities, industry, and public and governmental bodies with interests in personal genomics and related ethical, legal, and social issues. Open Humans connects researchers and participants who wish to share data with other to advance human health.