Under a scenario of global climate change, LEAF main research goals are to design SMART landscapes; to apply strategies for biodiversity conservation, anticipating shifts on critical and endangered species and habitats; to improve sustainable crop productions, focusing on yield and the best management of resources, while aiming at a circular economy; to develop new processes to obtain healthy, safe, economic, and sensory appealing new and functional foods (and feeds) with impact on health. To address these challenges, aligned with SDG and the European Green Deal, LEAF brings together a multidisciplinary team that produces knowledge with impact in multiple contexts, from temperate and Mediterranean regions to subtropical and tropical countries. Research areas cover the entire food value chain, from farm to fork, including landscape planning and soil and water management at the basis, to the impact of food on human and animal health at the end: a) starting from the territory: sustainable, ecological and cultural planning of land use; landscape restoration; mitigation of water scarcity; innovation in soil remediation; mitigation of environmental impacts; new technologies for the treatment of effluents, sediments and organic waste; b) supporting good agricultural practices based on scientific evidence with: genetic bases and underlying molecular mechanisms; ecosystem regulation/support services, aligning resilience and sustainability with a focus on woody species; c) progressing along the value chain, from a circular economy perspective: development of innovative foods for niches and by 3D printing; edible films with bioactives; structured lipids; oenology; fermented foods; and bioactives.