Humanity and all life-supporting ecosystems in general are going through one of the most difficult challenges in recent history. One that is testing our global organizational systems and exposing the ever-growing economic, social and environmental gaps. As such, enterprises can no longer afford focusing solely on profits, but rather on the three dimensions of value-creation: the economic, the social, and the environmental. As the expectations for higher performance increase, so is the role of innovation. The Responsible Innovation Framework is an overarching guiding principle aimed to inspire for-profit enterprises to pursue innovation initiatives that support sustainable development and circular models as main drivers to accelerate value-creation on its three dimensions: economic, social, and environmental.