SilcsBio provides software and services for unlocking the full potential of computer driven drug design. Our algorithms for mapping proteins will provide you with a level of detail you have never before experienced. From our highly accurate free energy maps to conformational nuances revealing hidden pockets of opportunity, you will discover a whole new world of possibilities. Our main products are: SILCS (Site-Identification by Ligand Competitive Saturation): provides sophisticated chemical functional group mapping for proteins and other biological targets, yielding 3-D maps and quantitative data to assist in ligand design and optimization. Possible applications include: Database Screening, Ligand, Optimization, Fragment-based Ligand Design, and Pharmacophore Generation. Single Step FEP: Single Step free Energy Perturbation allows free energy calculations 1,000 times faster than with standard FEP. Evaluate thousands of ligand modifications per hour without compromising accuracy. CGenFF: The CHARMM General Force Field program generates comprehensive parameters and topology information for a wide range of drug-like molecules,.allowing their use in Computer-Aided Drug Design campaigns.