Approximately 350 biotech projects are developed by the iGEM community every year that tackle local challenges globally. Despite their immense potential for impact, many promising projects don’t go beyond the competition. The most significant progress in implementing these projects has been through iGEM’s entrepreneurial community who have created over a 150 startups over the past 15 years. The aim of the entrepreneurship program is to support the development of this community by increasing their impact so that we can accelerate our transition to a sustainable bioeconomy. We will achieve this through a combination of venture creation labs, mentor matchmaking and fast-track access to the leading accelerators in the Americas, Asia-pacific and Europe Middle East and Africa regions. The program will highlight and celebrate these founders with a Start-up Showcase at the Jamboree each year where they can connect with and inspire future generation of iGEMers to start their entrepreneurial journeys.