The Institut NeuroMyoGène (INMG) is a novel institute dedicated to the study of the nervous and muscular systems. It was created in 2016 in Lyon at the heart of a dense hospital network and of one of the biggest medical universities in France. The INMG goal is to unravel fundamental aspects of the cell biology of the muscle and nervous system from development to aging under normal and pathological conditions. Using a variety of invertebrate and vertebrate model systems, the INMG is conducting an integrated multidisciplinary research from gene to physiological functions. One of its priorities is to develop relevant strategies to decipher multiple forms of neuromuscular diseases, identify new therapeutic targets and foster novel strategies for innovative treatments. The INMG benefits from the integration of cutting-edge fundamental research teams and renowned clinicians, including the directors of three reference centers for neuromuscular diseases, paraneoplastic syndromes and genetic cardiac rhythm diseases. The INMG is a consortium of three research organizations : the CNRS, the INSERM and the University Claude Bernard in Lyon. The Institute also gets strong support from the French Association against Myopathies (AFM). It gathers 14 individual research teams and about 160 people. Within the next years the Institute will be able to host up to 250 people. Research Topics •Neuronal and muscular development •Synapse biology •Genome stability and maintenance in postmitotic cells •Cellular processes involved in normal and pathological muscle aging •Cellular excitability: from channels to integrated cellular physiology •Mechanisms of regeneration and their relevance for muscle pathologies •Improving diagnosis and treatment of patients