Nanobiose’s mission is to provide pharma, biotech and cosmetic companies with better tools to improve their in vitro analysis of efficacy / safety of drug candidates. Nanobiose develops SecretCells®, an innovative lab-on-a-chip system to evaluate secreted biomarkers from 2D or 3D perfused cells. SecretCells® combines a microfluidic biochip (where the perfused 3D cell cultures stand) and a removable biosensor for a multiplexed on-line biomarkers analysis. While better mimicking in vivo like conditions, SecretCells® allows more accurate and more predictive results for the evaluation of drug candidates at early stages. SecretCells® is a very flexible solution : - Any 2D/3D cell culture set up - Explants, spheroïds, organoïds, biopsies - Any cell exposure set up, from 1 to 24 hours - Customizable biosensor and reagents kits - Parallelize or serialize assay SecretCells® is easy-to-use : - Adaptable to existing lab equipment (fluorescence microsopes, incubators etc…) - Easy to manipulate with organizer tray - Open and accessible cell culture wells - Possibility to change biosensor without stopping the experiment Potential applications : - Efficacy/cytotoxicity assessment with reduced variability in the measures & better window (vs. 96-w plates) - Cytokines release studies - Study of exposure time vs doses effects - Co-cultures at a distance with intermediate biomarker assessment - Explants / biopsies SecretCells® is a unique patented tool to simultaneously assess the ability of the tested items to elicit / inhibit specific biomarkers responses and their cytotoxic potential. And much more. Contact us to know more : contact@nanobiose.com