The National Academies of Sciences, Engineering, and Medicine pilot initiative, “New Voices in Sciences, Engineering and Medicine” (SEM), will engage an initial diverse group of outstanding early-career SEM leaders to provide new perspectives on issues and public communication modes for the National Academies, and to help identify and try out activities designed to expand the diversity of expertise that is engaged in the convening and advisory functions of the National Academies. With support from the Gordon and Betty Moore Foundation, the initial group of 18 SEM early-career leaders will gather over a two-year period with a senior advisory committee to discuss key emerging challenges in science, engineering, and medicine, engage nationally with a wider group of young leaders from diverse groups, and attend international events on science policy.