EPFL launched the Center for Intelligent Systems (EPFL CIS) in October 2019. This center is a joint initiative of the schools of Architecture, Civil and Environmental Engineering (ENAC), Computer and Communication Sciences (IC), Basic Sciences (SB), Life Sciences (SV), and Engineering (STI) that integrates research in Artificial Intelligence (AI), Machine Learning (ML) and Robotics to foster integrative research streams leading to the development of Intelligent Systems. Intelligent Systems perceive their environment, can learn from the data they collect and adapt to the changing world around them. Intelligent Systems can take many forms. When available, such systems will have profound implications for many areas including manufacturing, transportation, commerce, employment, healthcare, government, legal, security, privacy, and education. Four integrative research pillars have already been launched since the inception of CIS: “AI for Medicine”, “Intelligent Assistive Robotics”, “Decentralized edge AI Infrastructure” and “Digital Twin”. Furthermore, the EPFL Center for Intelligent Systems supports its 70 associated professors in their teaching and training mission of future engineers/scientists.