The Big Data Institute (BDI) is a state-of-the-art building at Oxford University's Old Road Campus. This interdisciplinary research centre focuses on the analysis of large, complex, heterogeneous data sets for research into the causes and consequences, prevention and treatment of disease. To this end, BDI researchers develop, evaluate and deploy efficient methods for acquiring and analysing information for large clinical research studies. These approaches are invaluable in identifying the associations between lifestyle exposures, genetic variants, infections and health outcomes around the globe.