Instruct-ERIC is a pan-European research infrastructure in structural biology, making high-end technologies and methods available to all European researchers. Our aim is to promote innovation in biomedical science and we operate on a non-economic basis within the scope of the ERIC Regulation. Structural Biology is one of the key frameworks on which we interpret molecular and cellular functions. The main experimental technologies are complementary, and increasingly link detailed atomic structure with cellular context. Structural Biology is currently in the middle of a revolution enabled by significant advances in the tools (direct electron detectors in EM, advances in synchrotron sources and detectors, XFELs, ultra-high field NMR, super-resolution cryo-light miscroscopy). Instruct-ERIC provides open access to cutting edge structural biology, specifically supporting research that uses integrated approaches and technologies. It operates with the following principles: a) scientific excellence is our priority in the services we provide and the research we support; b) transparency, equality and legality is the cornerstone of our operational model. Instruct-ERIC is comprised of 10 Member States: Belgium, Czech Republic, Denmark, France, Israel, Italy, Netherlands, Portugal, Slovakia and United Kingdom and four Observers: Greece, Spain, Sweden and EMBL as an Observer International Organisation. Researchers from Instruct member countries can request access to the service/technologies offered through the Instruct-ERIC Centres.