The Chemical Probes Portal is a research gateway for sharing information and expert advice about small molecules used in biomedical research (chemical probes). The Portal seeks to increase the reproducibility of research using chemical tools through community curation and communication. The portal is designed to elevate the rigorous application of high quality chemical probes to scientific investigations, increasing reliability of experimental results and decreasing wasted time and money, and promote interaction between chemists and biologists who create and use chemical tools in research.