The Global Coalition for Radiotherapy (GCR) was formed in April 2020, to understand the challenges and opportunities facing radiotherapy delivery during the radical disruption of cancer services worldwide caused by the COVID-19 pandemic. Timely advice and experience of adapting radiotherapy during the pandemic was shared by front line radiation oncologists from around the world via 3-weekly video meetings and daily website updates of relevant publications As the world moved through the pandemic the GCR momentum grew and virtual meetings attracted those with responsibility for global radiotherapy delivery: industry, providers of care, global health care organisations, patient advocates and radiotherapy professional leaders. The need for a GCR in the post COVID-19 era is clear; a multidisciplinary group of leaders and a wide range of experts in radiotherapy to act as a hub of advice and collaboration to support the global radiotherapy community seize the opportunities for radiotherapy in technology advancement to adapt health care delivery.