ProtoLytic is driven by a core engine that correlates diagnosis with associated medical procedures, products, and drugs. The core engine algorithms use existing evidence-based guidelines to create a probability distribution for each diagnosis code and patient. ProtoLytic’s algorithms rely on industry-standard data to determine the relationship between different diagnosis codes and other data about the patient to form a unique decision support Plan. For example, the Plan created for a patient with osteoporosis who suffers a broken leg and weighs 300 pounds will be very different from the Treatment Plan for a 120 pound patient with a broken leg with no other medical conditions. The multi-faceted ProtoLytic system can serve both as an embedded part of a bill review or claims platform without the need for a stand-alone interface, or the client can use the system by accessing the ProtoLytic Client Portal.