Past, present and future infectious diseases diseases result in massive business losses. COVID-19 related business closures and partial reopening will cost the US  trillions of dollars in GDP.  Business are spending  millions of dollars on PPE, cleaning supplies and disinfectants. Vaccines take time to develop and are not sufficient to keep business open. Charis is a SaaS AI/Machine learning application that helps business manage the risk of infectious diseases. Charis makes visible the real time risk of infection for individual employees and Customers. Organizations are enabled to make data driven decisions for facility access and workforce management.