The Ghana Climate Innovation Centre (GCIC) is a pioneering business incubator and accelerator with a unique focus on supporting small and medium-sized enterprises (SMEs) in Ghana’s ‘Green Economy’. The Centre is an institute of Ashesi University, one of Africa’s leading liberal arts universities with a mission to raise ethical, entrepreneurial leaders with the courage to transform the continent. GCIC’s work is at the nexus of private enterprise, climate change, economic development, and ecological prosperity. We support an exceptional set of transformational businesses and entrepreneurs who are pioneering adaptive and mitigating solutions for climate change issues in Ghana. Since the commencement of business incubation activities in June 2017, GCIC has supported 101 enterprises in Ghana’s small and growing business sector that have climate innovation in five key economic sectors, namely: climate-smart agriculture, solar power, energy efficiency, domestic waste management, and water management and purification. To date, these enterprises have performed admirably to, inter alia, scale their businesses, generating cumulative revenues of over US$2.1m, sequester 14,500MTs of CO2 emissions, raised early or growth stage financing of over US$2m, created 733 jobs, and have served over 400,000 Ghanaian households with their climate-smart goods and services.