The Ontario Drug Policy Research Network (ODPRN) is a collaboration of established researchers from across Ontario that was formed to rapidly respond to policymakers’ needs for relevant research to guide and inform their decisions. We have the capacity to generate scientifically sound evidence related to real-world drug utilization, safety, effectiveness, and costs of drugs in Ontario, and have developed partnerships that allow us to engage in cross-provincial comparisons of drug safety and utilization. Our researchers have expertise in pharmaceutical utilization, outcomes, economics, and drug-policy research.