The seamless flow of health information between the different healthcare systems across Europe brings tremendous benefits to patients, as well as the doctors and nurses providing vital care. IHE-Europe is dedicated to interoperability in health information technology. It begins with an open process of developing integration profiles to assure IT systems can talk to each other. Then it requires testing these systems to verify that complex computer coding delivers the data. Finally, IHE-Europe actively promotes wider awareness and use of these methods for assuring continued conformance and compatibility. IHE integration and content profiles have been adopted by national and regional projects in countries such as Austria, France, Italy, Switzerland, Slovenia, Luxembourg, The Netherlands and considered by several others. These specifications provide the guidance necessary to implement specific standards and profiles in commercial and self-developed systems that will help realize efforts towards large scale interoperability of health information in Europe.