Ketamine is a safe and effective medication in the treatment of depression and pain disorders. Ketamine was first, and still is, an important human general anesthetic agent. It has been used in hospitals for the past five decades and has a proven record of safety. More recently it is being used to treat moderate to severe depression/anxiety, neuropathic pain, and the symptoms of PTSD. The small doses and methods of administration used to treat mental health issues differ greatly from those used in hospitals.