Massachusetts General Hospital is home to the largest hospital-based research enterprise in the U.S., with an annual budget of over $912 million in 2017. The Mass General Research Institute comprises more than 8,500 researchers working across more than 30 institutes, centers and departments. As the oldest and largest teaching hospital of Harvard Medical School, Mass General has been a leader in bridging innovative science with highly advanced clinical care for more than 200 years. The Mass General Research Institute is built on a culture of excellence, compassion and groundbreaking scientific achievement. Our researchers work side-by-side with physicians—in the lab, in the clinic and at the bedside—harnessing the latest technological advancements to foster discovery at every stage. Among the medical and scientific “firsts” at Mass General are the first demonstration of ether as a general anesthetic, the first x-ray exposure produced in a hospital, the first antiseptic operating suite in the U.S., and the invention of MRI and fMRI imaging technologies. [More Facts at a Glance] Our location at the nexus of the Boston-Cambridge biotech cluster creates numerous opportunities to collaborate with partners from industry, venture capital, philanthropists, academia, foundations, governments, philanthropists and our community to prevent disease, make medical innovation sustainable, and find cures to improve the lives of our patients and those across the globe. The Research Institute Steering Committee is focused on establishing broader relationships with these potential partners, and finding new ways to connect them with our highly knowledgeable scientists and clinicians.