PTNG offers an intimate understanding of the structure and engineering of a wide range of proteins. Based on more than three decades of in-depth experience in rational engineering, structural and biophysical studies, we can support your company by guiding rational engineering and tailoring your molecules to specific applications. We can create mutagenesis strategies and engineer higher protein stability. For combinatorial library design, energetic calculations can aid in the choice of residues to be randomized. This approach may help focus the library, thus saving time and money in the laboratory. During post-selection, molecules can be subjected to computational “triage” before entering lengthy and costly experimental analysis. Our workflow uses molecular modelling approaches as well as molecular dynamics simulations. We apply our expertise in structural biology to provide strategies for structure elucidation, X-ray crystallography data analysis, structure determination, interpretation and analysis.