Medimprint develops innovative, non-lesion medical devices, for clinical research in brain tumors and neurodegenerative diseases. Based on a new concept, “the brain tissue imprint”, Medimprint’s products are the new generation of companion medical devices for personalized and targeted therapies. The non-lesion feature of this concept allows an exclusive in vivo access to : - Tumor heterogeneity - Peritumoral regions - Neurodegenerative regions for poly-omic molecular analyses. Medimprint’s technology breakthrough relies on the integration of functionalized silicon chips to surgical stylet for atraumatic sampling. Through an original « hide and display» principle, the brief and specific interaction of silicon with brain tissue enables a simple apposition contact and the collection of spatially-oriented imprints. The innocuity of these new medical devices has been recently validated in a phase 0 clinical trial.