The Procyon encapsulation device is a small, flat, thin, highly durable, flexible implantable chamber. It mitigates foreign body response, promotes the formation of vascular structures on its surface enabling the rapid diffusion of nutrients to cells inside and the rapid absorption of insulin (or other therapeutic molecules) secreted by the encapsulated cells while providing a barrier protecting them from attacks by the body’s immune system without the need for immunosuppressive drugs. The Procyon technology, designed with practical clinical use as a driver, includes integration of oxygen delivery to the implantable device, which enables tighter packing of cells while maintaining their viability and functionality.