The Indiana Clinical and Translational Sciences Institute, the Indiana Department of Health, and the IU Simon Comprehensive Cancer Center have come together to improve health in Indiana by forming Connections IN Health. This alliance unites the state’s health coalition development work, and the IUSCC’s community and engagement initiatives with that of Indiana CTSI. Connections IN Health is led by the Indiana CTSI’s Community Health Partnerships program, which works to improve health in Indiana through community-university partnerships and community-based health research. Connections IN Health supports stakeholders, organizations, advocates, and residents as they come together to improve health and address chronic diseases. Connections IN Health facilitates collaboration within communities by connecting stakeholders with evidence-based practices, identifying funding sources, and addressing health equity for all. Connections IN Health includes four statewide chronic disease initiatives: The Indiana Joint Asthma Coalition, the Health Equity and Cancer Control Initiative, the Hoosier Health and Wellness Alliance, & the Cardiovascular and Diabetes Coalition of Indiana. This project was funded, in part, by grant(s) NUE1EH001382, and/or NB01OT009281 from the Centers for Disease Control and Prevention and with support from the Indiana Clinical and Translational Sciences Institute funded, in part, by award number UL1TR002529 from the National Institutes of Health and National Center for Advancing Translational Sciences, Clinical and Translational Sciences Award. The views expressed in written conference materials or publications and by speakers and moderators are solely the responsibility of the author(s) and do not necessarily reflect the official policies or views of the Department of Health and Human Services or the National Institutes of Health nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.