The Sussex Drug Discovery Centre (SDDC) is a fully integrated group of drug discovery scientists, equipped with industry standard equipment and capabilities, based at the University of Sussex. Our goal is the discovery of novel therapeutics for diseases with high unmet medical need. The core aim of the centre is to deliver mature drug discovery assets for subsequent partnering and onward development. Central to this is the generation of a highly differentiated and commercially attractive portfolio – the group has adopted two strategies to deliver this: New approaches to old targets – many attractive and validated targets are yet to be targeted by marketed medicines; the group has programs aimed at delivering best in class molecules with the potential to reach market New approaches to new targets – collaborations with basic and clinical research scientists in Sussex and outside is delivering novel and structurally-enabled targets to start discovery activities We also play a strong role in the delivery of new chemical probes to assist target validation, particularly through our PhD studentship projects.