SBI established in 2009 under the Science Foundation Ireland CSET programme has successfully developed an integrated mathematical modelling and experimental research programme focusing on the design of new therapeutic approaches to cancer, degenerative and inflammatory diseases based on a systems level, mechanistic understanding of cellular signal transduction networks. SBI is one of the few centres in Europe with the necessary in house expertise, technologies and capabilities to apply systems biology approaches to mammalian models. It’s recognition internationally within the field of systems biology led to the Centre’s invited participation in three large European funded consortia initiatives in 2012 namely the ITFoM, CASyM and ISBE, the last of which is included on the ESFRI 2010 Roadmap. Research carried out at the Centre, significantly contributed to two successful large EU-FP7 multi-partner health proposals namely ASSET and PRIMES, both of which are coordinated by SBI and have a funding allocation in the region of €12 million each. Since its inception in 2009, SBI has built up a highly skilled international work-force of approx. 80 staff, many of which have secured independent funding and contributed to SBI’s impressive track record to date