Praxis AI is a transformative 21st Century portal dedicated to leveraging AI and Data Science to: 1) Cure Cancer… with Computational Biology programs and access to data-intensive computing clouds, including a Coronavirus SuperLab; 2) Empower the Digital Generation… with 21st Century contemporary digital learning journeys, collaborative LiveLabs, and faculty training in the Virtual Classroom; and 3) Transform Research… with Democratized Skills and Data Intensive Computing for Domain Research in biotechnology, energy, GIS, finance, and social sciences.