HSR.health is an innovative Health Tech start-up supporting COVID-19 response efforts in the US and globally. Over the course of the pandemic, we have helped identify the transmission and mortality risk of COVID-19 globally, the level of medical devices (e.g., ventilators), medical supplies (e.g., PPE), and healthcare staff to effectively treat patients at specific medical facilities, and have also provided health-risk data and insights to industry. Based on these efforts, we have identified the signals of human-to-human transmission of contagious infections. We seek funding to build a Global Early Warning & Response Platform that can alert on these signals and guide response & recovery efforts for Pandemic, Endemic, and Emerging disease outbreaks. Designed as a Blockchain-enabled, AI-powered Spatial Data Infrastructure that merges broad and diverse health, social, and environmental datasets, the Platform will represent a revolutionary advance in health risk analytic capabilities.