Powered by state-of-the-art machine learning, deep learning, and analytics, CLAIRE drives faster and more accurate healthcare data to revamp chronic disease management and thereby improve patient treatment outcomes. CLAIRE develops the AI-driven knee osteoarthritis (KOA) management system to enhance the interplay between primary and secondary healthcare. We aim to facilitate early diagnosis with personalised treatment protocols, but also aid in accurate case referrals and triage. In conjunction with our self-management mobile application, we empower KOA patients to take an active role in managing their health, by providing a streamlined rehabilitation process with in-app risk assessment, individualised health education, and an online reservation platform for healthcare professionals. Our data-driven approach also welcomes insurers to adopt accurate insurance price estimation. CLAIRE is now on track to become a successful start-up company and consists of staff members from interdisciplinary backgrounds. Within the first year of founding the company, the talented team had already developed the prototypes for the AI system and mobile application. This convinced healthcare industry leaders, public health experts, as well as primary and secondary healthcare institutes to become collaborating partners. CLAIRE is also awarded and secured a plethora of entrepreneurship awards, innovation awards, academic presentations, project showcases, and media coverages. Their success story has meant that the company is constantly in the limelight in this specialist field. In addition, The Hong Kong Trade Development Council has assist with the expansion of the venture into the US, Australia and New Zealand.