Prize4Life seeks to create breakthroughs in effective treatments for Amyotrophic Lateral Sclerosis (ALS, or Lou Gehrig's Disease) using the leverage of large inducement prizes. Instead of recognizing historical accomplishments, Prize4Life has a simple formula for transformational change. We design and launch prizes that we believe are achievable in a 2-3 year timeframe and then recruit teams to compete for the prize purse. The first team to find and demonstrate the required breakthrough wins the prize.