In July 2010, Children’s National was awarded the prestigious Clinical and Translational Science Award (CTSA) grant, from the National Center for Advancing Translational Sciences (NCATS), to establish the Clinical and Translational Science Institute at Children’s National (CTSI-CN). The CTSI-CN is a partnership between Children’s National and The George Washington University and recognizes the outstanding strengths in clinical and translational research that will be further enhanced. The vision of CTSI-CN is to promote innovations that speed the translation of research into improved child, family, and community health. The CTSI-CN offers unique resources in translating discovery to improved health. It provides highly integrated, cost-effective, investigator-focused resources designed to overcome research barriers, promote collaborative research, and provide research training with a special focus on children’s health. With an emphasis on health disparities and childhood antecedents to adult diseases, CTSI-CN builds upon its pediatric research strengths in areas such as rare diseases, asthma, and neuro-developmental disabilities to collaborate with a national network of 1,200 community health centers. The mission of the CTSI-CN is to foster broad collaborative investigation that accelerates discovery and drives dialogue across the bench, bedside, and community continuum.