CHARM-EU is a Challenge-driven, Accessible, Research-Based and Mobile European University, formed by five research-based universities: Universitat de Barcelona Trinity College Dublin Utrecht University Eötvös Loránd University International Université de Montpellier CHARM-EU expects to innovate on education and learning. Students of CHARM-EU are active, independent partners in learning. They can customise learning pathways to fulfil their professional and educational ambitions and support their personal needs. Students and partners contribute to curriculum design, development, implementation and evaluation. The content of CHARM-EU programmes focuses on creating solutions to support the Sustainable Development Goals of the United Nations. Flexibility, accessibility and mobility are enabled by technology and built into the educational experience. CHARM-EU will offer a learning experience that, having mobility and inclusivity at its core, is based on the implementation of a transformative approach to program and curricula design, and flexible, skill-oriented modularised structure. The European Universities Initiative launched in 2018, co-funded by the Erasmus+ project, is designed to strengthen mobility of students and staff, and foster the quality, inclusiveness and competitiveness of European higher education. CHARM-EU represents a Challenge-Driven, Accessible, Research-based and Mobile model for the co-creation of a European University aligned with the European Values, the European Green Deal and the Sustainable Development Goals (SDGs).