The University of Wisconsin-Madison Global Health Institute (GHI) works at the intersection of health, equity, and sustainability. Emerging infectious diseases such as COVID-19. Adequate food and safe water. Access to education. Women’s well-being. Childhood mortality. Biodiversity loss. Climate change. Addressing these major public health challenges demands reaching across disciplines, across the urban-rural divide and across international boundaries to intentionally collaborate to ensure sustainable health for all—all people, all life, and the planet that sustains them. GHI improves and inspires collaboration across campus and communities, educates tomorrow’s leaders and supports research and outreach to address community needs and improve well-being for all. The UW-Madison Global Health Institute is an idea born in Wisconsin—and it is a global manifestation of the Wisconsin Idea.