The University of South Carolina Big Data Health Science Center (BDHSC), as part of UofSC’s Excellence Initiative, serves as a campus-wide interdisciplinary enterprise that conducts cutting-edge research and discovery, offers professional development and academic training, and provides service to the community and industry. The BDHSC consists of five content cores (Electronic Health Records Core, Genomics Core, Bionanomaterials Core, Geospatial Core, and Social Media Core) and two functional hubs (Technology Hub and Business/Entrepreneurship Hub) that promote the utilization of Big Data analytics in health-related research, service, and academic training. Our mission is to be an innovation-driven enterprise that can facilitate and accelerate a sustained, high-caliber transformation of the UofSC into a global leader in big data health science.