The ARC CoE for Plant Success in Nature and Agriculture will make significant advances in the emerging fields of evolutionary systems biology (how plants work and evolve) and predictive analytics (mathematics) to deliver novel strategies for improving ecosystem management, crop resilience and yield. Parallel advances in legal and social frameworks will modernise outdated precedents in these areas, enabling truly impactful research to be fully recognised, with greater scope for commercialisation and public uptake. Through strong industrial and global partnerships and interdisciplinary collaborations, mentoring and communication, the Centre for Plant Success will transform plant science for the next generation.