The International Institute for Sustainable Laboratories (I²SL) is devoted to the principles of sustainable laboratories and related high-technology facilities, from design to engineering to operation. Through worldwide partnerships and the exchange of technical expertise, I²SL will encourage the development of high-tech facilities that address the rapid pace of science, medicine, research, and development in an ever-changing and dynamic environment. Mission: To engage all stakeholders in advancing the safety and sustainability of laboratories and other high-tech facilities globally. Vision: I²SL will be the global leader and primary resource connecting all stakeholders and providing information and education to ensure safe, sustainable laboratory design, operation, and use.