ChemBio Discovery Solutions is a professional consultancy and contract research platform founded in 2015 to offer computational modeling services and solutions for small-molecule and biologics (antibody) drug discovery research. Our main mission is to help our clients by providing specialised computational chemistry and biology services, to rationally and economically tackle the design and discovery obstacles facing drug discovery scientists. We promise to be highly flexible with our working business models by offering our services (under confidentiality agreements) on a retainer basis (dedicated time for a fixed monthly rate), per project basis (short- and long-term plans), or as per individual needs of clients and project. Our clients include pharmaceutical & biotech companies (small-to-medium size in general), academic research institutes, universities, government laboratories and regulatory institutes. We offer following drug design and discovery services to our clients: – Hit-to-Lead discovery and optimization – Structure-based / Ligand-based design and discovery – Combinatorial library design: focused virtual libraries with synthetic feasibility – ADME/Tox evaluations, drug repurposing – Feasibility and exploratory studies on specific Targets of Interest (TOI) – Bioinformatics: sequence alignment, analysis, and manipulation, secondary structure prediction, homology modeling. – Biologics: antibody modeling, humanization, protein/ peptide-protein docking, thermal stability enhancement, affinity maturation, aggregation propensity hot-spots (to improve solubility), proprietary peptide QSAR modeling (CoRIA: Comparative Residue Interaction Analysis). – Provide expert consultation on selection, training & use of software, to address your research needs. – Provide expert advice and project support to nucleic acid macromolecule (RNA, DNA) targeting.