Vaccines (ISSN 2076-393X) has had a five-year history of publishing peer-reviewed state-of-the-art research that advances the knowledge of immunology in human disease protection. Immunotherapeutics, prophylactic vaccines, immunomodulators, adjuvants, and the global differences in regulatory affairs are some of the highlights of the research published that have shaped global health. Our open access policy allows all researchers and interested parties to immediately scrutinize the rigorous evidence our publications have to offer. We are proud to present the work and perspectives of many to contribute to future decisions concerning human health. Our aim is to encourage scientists to publish their experimental and theoretical results in open access form in as much detail as possible. The full experimental details must be provided so that the results can be reproduced and computed data or files regarding the full details of the experimental procedure can be deposited as supplementary material.