Confidence in Commercial Potential: Answering 5 Questions Even at early stages of development, confidently answering 5 questions about commercial potential is critical for high leverage audiences: Boards, Investors, Analysts, Strategic Partners. Five Questions: 1. What is the Market Size? Key Issue: Typical epidemiology studies are not designed to support commercial forecasting. 2. What is the Market Structure? Key Issue: From clinical trial design through approved payer coverage, market segments (patient age, phenotype) ultimately define the addressable opportunity. 3. Can You Explain Your Market Share Assumptions? Key Issue: The market research rule-of-thumb of just cutting the preference share in half does not generate confidence. A structured and defensible preference share calibration will. 4. How Will You Set/Defend Your Price? Key Issues: Proper design of payer market research, analogue selection and value framework. 5. Have You Developed Global Projections? Key Issue: Your development asset likely has ex-US value, regardless of your commercial intentions. Be ready when an interested party emerges unexpectedly. Our efficient and innovative methodology can help you credibly assert ex-US projections even at an early development stage. Sentero’s partners have extensive experience in diligence, transactions, commercial analytics and launches across ultra-rare, gene therapy, oncology, specialty and primary care markets. We have developed hundreds of global product forecasts with an approach demonstrated to provide management with the best insights into commercial potential. Applications: 1. Optimize clinical trial design to ensure critical patient segments are included and commercial obstacles are addressed 2. Enhance value narrative for fundraising & successful M&A transactions 3. Prepare for successful commercial launch Expectations get set early. Let us help you get it right!