The European Paediatric Translational Research Infrastructure, EPTRI, is a project that arises from the need to find answers to the serious lack of medicines for children in EU and worldwide. It aims to propose developmental models for a future research infrastructure focused on paediatric medicines, integrating technology-driven aspects with clinical trials. ID-EPTRI is coordinated by Consorzio per Valutazioni Biologiche e Farmacologiche (CVBF) and has received funding from the European Union’s H2020 programme under grant agreement 777554. It involves 26 partners from 19 EU/Associated countries.