The Institute for Applied Computational Science (IACS) at the Harvard John A. Paulson School of Engineering and Applied Sciences is the home for students and faculty who are tackling major challenges in science and the world through the use of computational methods. We train graduate students to solve real-world problems and conduct innovative research by using mathematical models, algorithms, systems innovations and statistical tools. Embedded within a large liberal arts research University, IACS serves as a focal point for interdisciplinary collaborations in computational science and data science at Harvard and the Boston area community.