Nitric Oxide Services has access to proprietary nitric oxide-donor compounds, synthesis facilities and analytical methods and instrumentation which provides a comprehensive platform to meet the challenge of any NO-based research project from inception to completion. CAPABILITIES AND EXPERTISE 1. Bioanalytical detection of NO, NO2, nitrate/nitrite/nitrosothiols, NO-heme, and other NO-metals in biological fluids such as blood, urine, cerebrospinal fluid, and bronchial-alveolar lavage, as well as cell culture media and tissue homogenates 2. Cell viability and cytotoxicity studies including dose and time-response, and determination of ID50 assessing gaseous NO/NO-donors in mammalian and prokaryotic cells 3. Custom synthesis and purification of NO-donor compounds from milligram (GLP) to kilogram (cGMP) scale 4. Characterization of NO-donors and kinetic NO-release profiles using multiple analytic platforms such as HPLC, UV/Vis, FTIR, and head-space chemiluminescence analysis 5. Design of custom projects tailored for NO delivery in a variety of R&D healthcare applications 6. Design and execution of pharmacokinetic and pharmacodynamic studies of NO donors undertaken with full IACUC approvals 7. Validation and analysis to support research & development, clinical and commercial needs 8.Gold standard analytical instrumentation and testing methods