The Harry Crossley Children’s Nursing Development Unit is a nurse-led academic unit in the Department of Paediatrics and Child Health at The University of Cape Town, situated at Red Cross War Memorial Children's Hospital in Cape Town, South Africa. Ensuring the health and well-being of children is globally recognised as critical for achieving sustainable humanity. With nurses often being the mainstay of care for hospitalised children, building and supporting an educated, competent and motivated children’s nursing workforce is essential for improving infant and child health outcomes. This is especially true in high-burden, low-resourced countries. So for this reason, the Harry Crossley Children’s Nursing Development Unit works with interdisciplinary colleagues from both academic and clinical settings to strengthen the practice of children's nursing across Sub-Saharan Africa.