Unlocking the world’s genomic information to drive targeted treatment of diseases. We provide the organizing framework, focus, and leadership for the next great leap in the science of genomics and its implications for human health to carry out our goals: Accelerate the power of the global research community to solve today’s intractable health problems. Lead the national and international effort to break down institutional silos where genomic information is now isolated. Enable the secure sharing and analysis of genomic data on a global open-source federated network. Tackle head on the most fundamental societal questions evoked by the advent of a universal genomics technology. As always, all that we learn and create we will openly share with the world. We are a public institution dedicated to creating a healthier world and a healthier society.