The Center for Health and Humanitarian Systems (CHHS), an Interdisciplinary Research Center at Georgia Tech, has been a global leader in research, education, and outreach. It focuses on (i) developing and applying data-driven quantitative methods and tools to aid in decision-making, (ii) offering educational programs and materials for learners from various backgrounds and stages in their careers, and (iii) development and sharing of new knowledge and best practices in health systems and humanitarian systems. Together with our students, partners, and collaborators, CHHS is well positioned to address the vast challenges and emerging directions in health and humanitarian systems, following a data-driven quantitative systems approach, developing rigorous and scalable methodologies and working on successful translation to practice. We are excited about the opportunities to continue and expand our educational, research, innovation, and outreach initiatives to make a significant impact for generations to come.